A Design of Experiments Approach to Analyze the Effects of Hydroxyapatite and Maleic Anhydride Grafted Polyethylene Contents on Mechanical, Thermal and Biocompatibility Properties of Green High-Density Polyethylene-Based Composites

Composites based on green high-density polyethylene (G-HDPE) and hydroxyapatite (HA) compatibilized with maleic anhydride grafted (HDPE-g-MAH) were developed in this work. The main objective was to evaluate the effects of HA HDPE-g-MAH contents mechanical thermal properties hydrolytic degradation composites through design experiments statistical analysis, as well hemolytic stability. Hydroxyapatite acts a reinforcing agent for G-HDPE matrix while compatibilizing agent, improving dispersion particles polymer thus increasing properties. crystallization temperature degree crystallinity increased addition HA, suggesting filler heterogeneous nucleating agent. Hemolysis tests performed composite sample best performance did not indicate significant degradation, which suggests is promising material be used bone tissue engineering, application implants grafts.